Az optimális környezeti magnézium ellátottság daganatellenes hatása

The author summarizes the literature data of magnesium (Mg) effect on different cancers based on its antiproliferative properties supported by indirect own data. Epidemiologic studies show a significant decrease of cancer mortality due to dietary and/or extra Mg supplementation. Own data demonstrate that in 108 cases of hepatic, lung, colorectal, mammary, gastroesophageal, prostate, pancreas cancer, acute myeloid leukaemia, only 29 patients’ serum Mg level was above the „optimal” value, such as 0.9 mm/L. None of them had serum Mg level above 1.15 mm/L. In selected Hungarian population (5469 persons), serum Mg level was in 1.08 percent above 1.00 mm/L, while in 6,55% was optimal, in 92,37% was under the desirable level. One could hypothesize that elevation of serum and consequently interstitial-intracellular Mg++ level above the normal (1-, 0.4-0.6 mm/L, respectively), may stop pathologic proliferation of cancer cells via dissecting of tumour microenvironment and could induce programmed cell death in them. Mg encapsulating nanoparticles, permeation enhancers to intestinal mucosa are not necessary to the effect of Mg as a nature’s physiologic calcium channel blocker in human body affecting and modulating many enzym processes and cell membrane channels due to its highly variable intracellular concentration (from 0.4-0.6 mm/L to >6.5 mm/L). It’s safe and inexpensive treatment against pathologic cell proliferation