Stroke outcome related to initial volume status and diuretic use
- Renner, C.J.
- Kasner, S.E.
- Bath, P.M.
- Bahouth, M.N.
DOIAbstract
Background: We hypothesized that stroke outcome is related to multiple baseline hydration-related factors including volume contracted state (VCS) and diuretic use. Methods: We analyzed a prospective cohort of subjects with ischemic stroke <24 hours of onset, enrolled in acute treatment trials within the Virtual International Stroke Trials Archive. A VCS was defined based on BUN-to-creatinine ratio. The primary endpoint was modified Rankin Scale (mRS) at 90 days. Primary analysis employed generalized ordinal logistic regression over the mRS range, adjusted for THRIVE score, onset-to-enrollment time, and thrombolytic usage. Results: Of 5971 eligible stroke patients, 42% were taking diuretics at the time of hospitalization and 44% were in a V...
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