GSTP1 Rs1695 Polymorphism, Oxidative Stress Markers, and Antioxidants in Coronary Artery Disease

Oxidative damage is among the essential factors in the progression of cardiovascular disease. Objectives: This study aims to evaluate the molecular role of GST genotypic polymorphism involved in the development of CAD. This study also aimed to compare the levels of oxidative stress and antioxidant markers in subjects with CAD with age and sex-matched controls. Result: There was no significant difference in allele frequency (p= 0.85) or genotype frequency (p= 0.85) between the examined case and control groups. Compared to healthy controls, F2-Isoprostanes and MDA levels were considerably elevated in individuals with coronary artery disease. CAD patients' GST, SOD, Vitamine E, and Vitamin C levels were considerably lower than in normal control subjects. Conclusion: This study observed that oxidative stress markers were significantly higher, whereas, in CAD patients, enzymatic and nonenzymatic-enzymatic antioxidants were significantly lower. This study could not find a good connection between GSTP1 gene polymorphism rs1695 and coronary artery disease