Development And Validation For Simultaneous Estimation Of Telmisartan And Hydro-chlorothiazide In Bulk Drug And Pharmaceu-tical Dosage Form By Uv- Spectrophotometry

A simple, accurate and precise simultaneous analytical method has been developed for simultaneous determination of Telmisartan and Hydrochlorothiazide in bulk drug and tablet dosage form. The wavelength selected for these drugs were 295.5 nm and 273.0 nm respectively. The linearity at selected wavelength lies between 10-90 µg/ml for Telmisartan and 5-60 µg/ml for Hydrochlorothiazide. The concentrations of these drugs were evaluated in laboratory mixture of reference standard and different marketed formulation. Recovery studies confirmed the accuracy of proposed method. Precision of the method was found as the values within acceptable limit. Thus the proposed method and results were validated as per ICH guidelines. Statistical analysis proves that the method is reproducible and selective for the simultaneous estimation of Telmisartan and Hydrochlorothiazide