Development And Validation Of Rp-hplc Method For Simultaneous Estimation Of Risperidone And Haloperidol In Tablet Dosage Forms

A new, simple and sensitive reverse phase high performance liquid chromatographic (RP-HPLC) method has beendeveloped for the separation and quantification of Risperidone(RIS) and haloperidol (HPD) in tablet dosage form. Thedetermination was carried out using XBridge C18 [4.6 x 150 mm] column as a stationary phase and mobile phase comprisedof Methanol: triethyl amine Buffer (60::40) and the pH of triethylamine adjusted to pH2.5 using orthophosphoric acid. Theflow rate was maintained at 1.0 ml/min and the eluent was monitored at 260nm.The retention time of RIS and HPD were1.82 min and 4.42min respectively. The method was validated in terms of linearity, precision, accuracy, specificity androbustness. The method was linear and for precision studies; RSD for RIS AND HPD were 0.02 and 0.04 respectively. Thepercentage recoveries for both drugs from their tablets were 100.80 and 99.76 % respectively