Unimolecular Decomposition of M+ and [m+h]+ Species of Some Fluorosubstituted Acyclic Nucleoside Analogs

Electron ionization and fast-atom bombardment mass spectrometry are shown to provide a valid analytical tool for the structural characterization of the title compounds. In fact, diagnostic fragmentation pathways were observed depending on the presence of different substituents (benzyloxy, p-tolylthio, p-tolylsulphinyl) as well as of different bases. Regioisomeric compounds could be differentiated by kinetic energy release measurements