State of the Hemostatic System in the Newborn Calves with Diverse Birth Weights

The studies on the peculiarities of hemostatic indices in calves (n=250) of Holstein- Friesian breed with diverse birth weights were conducted under the conditions of a dairy farm with the aid of generally accepted clinical, instrumental and laboratory methods. The research has demonstrated that in comparison with the adults the newborns weighing from 36.5 to 29 kg revealed a diversity of hemostatic indices but generally there was a functionally acceptable balance of its links without a tendency to coagulopathy or thrombosis. Fetal growth restriction in cattle with low birth weight has a significant effect on the hemostatic system. Insufficient weight of more than 7 % provokes hypercoagulability syndrome which is caused by increased levels of adrenalin, toxic products of impaired metabolism and destruction of erythrocyte membranes. The newborns with lower weight demonstrated signs of primary coagulopathy conditioned by functional inferiority of the organs in which the synthesis of coagulation factors occurred that led to the development of disseminated intravascular coagulation. The revealed dependence of the hemostatic disorders evidence on the severity of weight insufficiency indicates coagulopathy, emerging in epigenetics of the main pathology after primary damage and conditioning the severity of the newborns' state, as one of the main mechanisms of hypotrophy pathogenesis