Development and Evaluation of Medicated Chewing Gums of Fluconazole for the Treatment of Oral Candidiasis

Chewing gum is one of the most popular dosage form, used for delivering the many active components. Most of thechewing gums were used for smoking cessation (containing the nicotine) and also used for oral and dentalhygiene.Fluconazole is an anti-fungal drug. It is one of the active ingredients used to treat oral candidiasis. In the presentwork medicated chewing gum of fluconazole was developed to treat oral candidiasis. The study includes formulation and evaluation of medicated chewing gum of fluconazole.The chewing gum formulations were made using a gum base. The concentration of gum base was varied in the formulation to study its effect on in-vitro drug release. Formulations were developed by conventional/traditional method.The prepared formulations were evaluated for various parameters like physical appearance, weight variation, drug content in-vitroandin-vivodrug release behavior. Stability studies were conducted. From this study it could be concluded that it is possible to design medicated chewing gum containing fluconazole, mainly for the treatment of oral candidiasis and related conditions where efficacy and enhanced patient compliance are of paramount importance