To Study the Effectiveness of Intralesional Verapamil in Resolution of Plaque of Peyronie's Disease

The prospective study was conducted to study the role of intralesional verapamil in resolution of plaque of peyronies disease. Verapamil's effectiveness is predicated on its ability to affect fibroblast function on multiple levels, including cell proliferation, extracellular matrix protein synthesis and secretion, and collagen breakdown. Calcium antagonists may thus have the potential to reduce, halt, or even reverse plaque formation and Peyronie's disease progression. According to the intralesional verapamil injection therapy, the majority of men with Peyronie's disease who receive treatment experience long-term pain relief, curvature reduction, and enhanced sexual performance. Intralesional verapamil injection therapy resulted in reduction of pain in 92% cases, reduction of plaque size in 80% cases, reduction of penile curvature in 75% cases and improvement in erectile dysfunction in 60% cases