NEOANGIOGENESIS IN TEMPORAL BONE CARCINOMA: THE PROGNOSTIC ROLE OF CD105

Objective: Temporal bone squamous cell carcinoma (SCC) accounts for less than 2% of all head and neck tumors. Its biological parameters should be investigated because clinicopathological factors are often inaccurate for the purposes of its prognosis. CD105 is a proliferation-associated protein expressed in angiogenic endothelial cells, and a potential prognostic indicator for several solid malignancies. The present study is the first to investigate the prognostic role of CD105 expression in temporal bone SCC. Study Design: Retrospective clinicopathological investigation. Setting: Tertiary referral centers. Patients: Twenty consecutive operable patients with temporal bone SCC. Intervention: CD105 immunohistochemical expression in primary temporal bone SCCs was assessed using image analysis. Main outcome measures: CD105 expression was correlated with conventional clinicopathological and prognostic parameters. Results: Using the revised Pittsburgh staging system, T and stage correlated with local recurrence rate (p=0.0001 and p=0.0001, respectively) and DFS (p=0.043 and p=0.018, respectively). The recurrence rate was significantly higher (p=0.038) and the DFS shorter in patients with CD105 expression 659.44% (p=0.038) than in cases where it was