Apraxia of eyelid closure in autopsy-confirmed vascular progressive supranuclear palsy

Vascular progressive supranuclear palsy (PSP) is a rare condition that may mimic idiopathic PSP and is caused by diffuse subcortical ischemic white matter lesions. Among clinical signs distinguishing neurodegenerative from vascular PSP, the type of supranuclear impairment of lid motility may be of diagnostic value. We describe the clinical features and the neuropathological findings of a 71-year-old man diagnosed with vascular PSP and discuss the pathophysiology of apraxia of eyelid closure