Isotonic inference concerns situations in which a set of parameters is assumed, a priori, to satisfy certain order restrictions. In the most common case, where populations are arranged in ordered groups, the parameter of interest is assumed to change monotonically with the ordering of the groups. It is then reasonable to take account of the order restrictions in making inferences about the group parameters, such as point or interval estimations or significance tests. Isotonic inference represents a statistical tool of great value in many areas of applied research, especially within the fields of genetic epidemiology and molecular genetics. The purpose of this book is to illustrate a new statistical approach to test allelic association and g...
The most important decision faced by large-scale studies, such as those presently encountered in hum...
SummaryFamily-based tests of association provide the opportunity to test for an association between ...
We use likelihood-based score statistics to test for association between a disease and a diallelic p...
Isotonic inference concerns situations in which a set of parameters is assumed, a priori, to satisfy...
In this paper we present a permutation solution to an isotonic inference problem very usual in assoc...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
In this paper we provide some new statistical results for hypotheses testing in genetics particularl...
In this paper we provide some new statistical results for hypotheses testing in genetics particularl...
In this short report, we address some practical problems in performing likelihood-based allelic asso...
SummaryHigh-resolution mapping is an important step in the identification of complex disease genes. ...
Additional information about risk genes or risk pathways for diseases can be extracted from genome-w...
Association tests of multilocus haplotypes are of interest both in linkage disequilibrium mapping an...
There are a number of approaches to detect candidate gene-disease associations including: (i) 'per-g...
[[abstract]]Current family-based association tests for sequencing data were mainly developed for ide...
The most important decision faced by large-scale studies, such as those presently encountered in hum...
SummaryFamily-based tests of association provide the opportunity to test for an association between ...
We use likelihood-based score statistics to test for association between a disease and a diallelic p...
Isotonic inference concerns situations in which a set of parameters is assumed, a priori, to satisfy...
In this paper we present a permutation solution to an isotonic inference problem very usual in assoc...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
The genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage o...
In this paper we provide some new statistical results for hypotheses testing in genetics particularl...
In this paper we provide some new statistical results for hypotheses testing in genetics particularl...
In this short report, we address some practical problems in performing likelihood-based allelic asso...
SummaryHigh-resolution mapping is an important step in the identification of complex disease genes. ...
Additional information about risk genes or risk pathways for diseases can be extracted from genome-w...
Association tests of multilocus haplotypes are of interest both in linkage disequilibrium mapping an...
There are a number of approaches to detect candidate gene-disease associations including: (i) 'per-g...
[[abstract]]Current family-based association tests for sequencing data were mainly developed for ide...
The most important decision faced by large-scale studies, such as those presently encountered in hum...
SummaryFamily-based tests of association provide the opportunity to test for an association between ...
We use likelihood-based score statistics to test for association between a disease and a diallelic p...