Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts
- GRANDI, CLAUDIO
- BAIGUERA, SILVIA
- MARTORINA, F
- LORA, S
- AMISTA, P
- DALZOPPO, DANIELE
- DEL GAUDIO, C
- BIANCO, A
- DI LIDDO, ROSA
- CONCONI, MARIA TERESA
- PARNIGOTTO, PIER PAOLO
DOIAbstract
The aim of the present study was to investigate the influence of a decellularization protocol on the structure and the mechanical behavior of small-diameter (<6 mm) tibial calf arteries and veins. Calf vessels were decellularized by a detergent-enzymatic method (DEM), partially hydrolyzed with trypsin and subsequently cross-linked using poly(ethylene glycol) diglycidyl ether. Our results showed that i) the DEM can be considered a simple and valuable procedure for the preparation of complete acellular arteries and veins able to preserve a high degree of collagen and elastic fibers, and ii) poly(ethylene glycol) diglycidyl ether cross-linking treatment provides appropriate mechanical reinforcement of blood vessels. Histologically, the decellu...
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