Solubility Enhancement of Lornoxicam with Poloxamer 188 by Solvent Evaporation Method

This investigation aimed to enhance the solubility and bioavailability of the BCS class II poorly water-soluble drug Lornoxicam by solid dispersion (SD) techniques using Polaxomer 188 as a hydrophilic carrier. Solid dispersion of Lornoxicam was made through physical mixing (kneading method) and solvent Evaporation technique via different drug: carrier ratios. Prepared solid dispersion was characterized for solubility, drug content, percentage yield, and in vitro dissolution study. Solid-state characterization was performed by differential scanning calorimetry and Fourier-transform infrared spectroscopy. Lornoxicam's apparent solubility increased with an increasing level of carrier. A solid dispersion study revealed a better dissolution of lornoxicam than physical blends. In the phase solubility study, the drug demonstrated a higher solubility over phosphate buffer pH range 6.8 compared to distilled water. Solid Dispersion of Lornoxicam: Polaxomer188 solvent evaporation (1:3) showed maximum dissolving effectiveness between all solid dispersion and physical mixture. IR spectra showed no clear interaction between the drug and the polymer. Solubility increases with Solvent Evaporation than with physical mixing and alongside use of water-soluble polymer Polaxomer 188