Development and Validation of Uv Spectroscopic Method for the Estimation of Canagliflozin in Bulk and Tablets

The present work was aimed to develop and validate an improved UV Spectroscopic method for the determination of Canagliflozin in bulk and tablet dosage forms. The diluent used was Methanol: Distilled water (1:1) and the drug was estimated 224 nm. The developed UV Spectroscopic method for Canagliflozin used Methanol: Distilled water (1:1) as the diluent and estimated at 224 nm. Percent recovery for the drug at 80, 100 and 120 % levels was 99.82-100.09. % RSD for intra-day and inter-day precision were 0.75 and 0.84 respectively. Linearity was observed from 10-60µg/ml with a correlation coefficient of 0.999. LOD and LOQ were 0.33 and 1.00µg/ml respectively. The percentage purity of the drug was found to be 99.79 from the assay results. The method developed was simple, sensitive and cost-effective and could be used for the analysis of the drug in educational institutions