The challenge of very rare tumours in childhood: The Italian TREP project
- Ferrari, A
- Bisogno, Gianni
- DE SALVO, Gl
- Indolfi, P
- Perilongo, Giorgio
- Cecchetto, Giovanni
DOIAbstract
A national cooperative project on rare paediatric tumours (the TREP project) was launched in 2000 in Italy, with a view to improving the clinical management and the basic research on these 'orphan' tumours, defined as those childhood solid malignancies characterised by an annual incidence <2/million and not considered in other clinical trials. This paper describes the process that the group developed and the problems it had to face, and aims to stimulate a debate on the rationale, scientific relevance and feasibility of running scientific research programs on rare childhood neoplasms. In the first phase of its activity, the project developed diagnostic and therapeutic recommendations for each rare tumour and established a collaborative netw...
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