Study of Anti-diabetic Activity of Alstonia Scholaris (L.) R.BR. Root Extract

Complementary therapies are being investigated extensively in the treatment of chronic disorders like diabetes mellitus (DM). The anti-diabetic efficacy of a methanol extract of Alstonia scholaris root on normoglycemic, glucose-loaded, and streptozotocin (STZ)-induced diabetic rats was investigated in this work. Single and multiple doses of Alstonia scholaris root extracts at 200 mg/kg and 400 mg/kg were given to normoglycemic, glucose-loaded, and streptozotocin-induced diabetic rats. At various points following administration, blood sugar levels were measured. One-way analysis of variance (ANOVA) and Dunnett's t-test were used to statistically analyse the data. Significant was defined as a p value of less than 0.05. In normoglycemic rats, the extract reduced blood glucose levels by 6.3 percent (p < 0.01) and 7.12 percent (p < 0.01) after 8 hours at doses of 200 mg/kg and 400 mg/kg body weight, respectively. The decline in blood sugar levels in STZ-induced diabetic rats was 44.28 percent (p < 0.01) and 56.66 percent (p < 0.001), respectively, at the same dosage level. During the research, the reference medication was glibenclamide. Thus, the hypoglycaemic activity of Alstonia scholaris root extract suggests that it could be used to generate a new herbal medication for diabetes treatment