Stat3 expression in canine mammary gland tumors and mammary gland hyperplasia

Aim of this study was to detect by immunohistochemical methods STAT3 expression in canine mammary tumors and in canine mammary gland hyperplasia. Moderate to intense STAT3 protein labelling was detected in all epithlial neoplastic cells in canine mammary tumor. We observed a variable reactivity of the epithelial neoplastic component but a slight or negative staining in myoepithelial component in complex tumors. The bening tumors and mammary gland hyperplasia showed a more variable pattern of reactivity to STAT3 antibody