Figures 1.12 & 6.11 were re-used with the respective publisher's permission.HDAC4 plays an essential role in brain functions including neurodevelopment and memory formation, and increased levels of HDAC4 have also been associated with neurodegenerative disorders including Alzheimer’s disease. Histone deacetylases are enzymes that are traditionally known to regulate gene expression in the nucleus, however in neurons, HDAC4 shuttles between the nucleus and cytoplasm with a predominant distribution in the cytoplasm. Although studies have identified potential differences in subcellular function in which accumulation of nuclear HDAC4 has been shown to promote neurodegeneration, while cytoplasmic HDAC4 is neuroprotective, the mechanistic pathw...
Background: The homeobox gene homeobrain (hbn) is located in the 57B region together with two other ...
Background The Drosophila brain is an ideal model system to study stem cells, here called neuroblas...
<div><p>A growing body of research indicates that pharmacological inhibition of histone deacetylases...
Figures are re-used with the publishers' permission.The class IIa histone deacetylase HDAC4 has been...
Listed in 2017 Dean's List of Exceptional ThesesEpigenetic mechanisms are emerging as master regulat...
Figure 1.6 is re-used with the publisher's permission.Memory and cognitive disorders, such as Alzhei...
Intellectual disability (ID) is a neurodevelopmental disorder associated with many epigenetic regula...
SummaryNeuronal activity influences genes involved in circuit development and information processing...
In this thesis we first characterized neuronal functions for HPat/Pat1, a core component of RNA proc...
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neur...
Neurodegeneration is characterized by progressive loss of neurons. Genetic and environmental factors...
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs)...
Neuronal activity influences genes involved in circuit development and information processing. Howev...
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neur...
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs)...
Background: The homeobox gene homeobrain (hbn) is located in the 57B region together with two other ...
Background The Drosophila brain is an ideal model system to study stem cells, here called neuroblas...
<div><p>A growing body of research indicates that pharmacological inhibition of histone deacetylases...
Figures are re-used with the publishers' permission.The class IIa histone deacetylase HDAC4 has been...
Listed in 2017 Dean's List of Exceptional ThesesEpigenetic mechanisms are emerging as master regulat...
Figure 1.6 is re-used with the publisher's permission.Memory and cognitive disorders, such as Alzhei...
Intellectual disability (ID) is a neurodevelopmental disorder associated with many epigenetic regula...
SummaryNeuronal activity influences genes involved in circuit development and information processing...
In this thesis we first characterized neuronal functions for HPat/Pat1, a core component of RNA proc...
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neur...
Neurodegeneration is characterized by progressive loss of neurons. Genetic and environmental factors...
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs)...
Neuronal activity influences genes involved in circuit development and information processing. Howev...
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neur...
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs)...
Background: The homeobox gene homeobrain (hbn) is located in the 57B region together with two other ...
Background The Drosophila brain is an ideal model system to study stem cells, here called neuroblas...
<div><p>A growing body of research indicates that pharmacological inhibition of histone deacetylases...