International federation of genomic medicine databases using GA4GH standards

We promote a shared vision and guide for how and when to federate genomic and health-related data sharing, enabling connections and insights across independent, secure databases. The GA4GH encourages a federated approach wherein data providers have the mandate and resources to share, but where data cannot move for legal or technical reasons. We recommend a federated approach to connect national genomics initiatives into a global network and precision medicine resource.Funding: A.T. acknowledges funding support from Genome Canada, Genome Quebec, and the Canadian Institutes of Health Research. H.L.R. and A.J.H.P. acknowledge funding under NIH U41HG006834 and U24HG011025. M. Baudis acknowledges funding under the Bio-MedIT Network project of Swiss Institute of Bioinformatics (SIB) and Swiss Personalized Health Network (SPHN). M.L. acknowledges funding from the CINECA project (H2020 No 825775). M.S.C. acknowledges funding under NIH/NCI U01CA242954, NIH/NHLBI Fellowship 5118777. M. Brudno is a CIFAR Canada AI Chair. P.G. acknowledges funding from CIHR, Genome Canada, Wellcome Trust, and NIH. T.H.N. was funded by the Academy of Finland grant no 319968 and ELIXIR Europe 2019–2023 progra