Biological indices of kidney involvement in personnel exposed to sevoflurane in surgical areas

Abstract Background: Fluoride, a main metabolite, and one degradation product of sevoflurane (SEV), called Compound A, are known to cause kidney effects in experimental animals. Other than in volunteers and patients, no research is available on exposed workers. The possible effects on the kidney in workers exposed in surgical areas were studied. Methods: Subjects exposed to SEV and nitrous oxide (N2O) in surgical areas (N = 61) using open (N = 25) or semi-closed (N = 36) circuits were submitted to biological monitoring. The same biological indices were determined in 43 controls also. Sevoflurane (SEVU), nitrous oxide (N2OU), total urinary proteins (TUP), N-acetyl-\u3b2-D-glucosaminidase (NAGU), and glutamine synthetase (GSU) were measured in urine. Results: The mean values of environmental exposure were 31.3 ppm (range 0.9-111.6 ppm) for N2O and 0.28 ppm (range 0-1.88 ppm) for SEV. Exposed subjects had significantly higher excretion of TUP; a higher, not significant, excretion of GSU was also observed in subjects using open circuits. A significant correlation was found in all exposed subjects between NAGU and SEVU (r = 0.303, P < 0.05), GSU and N2OU (r = 0.382, P < 0.01) and, especially, GSU and SEVU (r = 0.650, P < 0.001). These correlations appeared to be influenced by the use of open circuits; infact, NAGU was well correlated to N2OU (r = 0.770, P < 0.001) and SEVU (r = 0.863, P < 0.001); GSU to N2OU (r = 0.468, P < 0.05) and SEVU (r = 0.735, P < 0.001). Conclusions: Results show that no relevant effect on the kidney is present for the levels of exposure studied. Nevertheless, correlation between dose and response urinary indices supports that SEV, other than N2O, may influence kidney function, especially when open circuits are used. \ua9 2003 Wiley-Liss, Inc