IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces the inflammasome and interferon-β responses. IFI16 also regulates cellular transcription and act as a DNA virus restriction factor. IFI16 knockdown disrupted the latency of Kaposi’s sarcoma associated herpesvirus (KSHV) and induced lytic transcripts. However, the mechanism of IFI16’s transcription regulation is unknown. Here, we show that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the KSHV genome during de novo infection and latency. The resulting depositions of H3K9me2/me3 serve as a docking site for the heterochromatin-inducing HP1α protein leading into the IFI16-dependent epigenetic modificati...
Human papillomavirus type 16 (HPV16) and other oncogenic viruses have been reported to deregulate im...
The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0...
Sensing of invading DNA virus genomes appear to be triggered by a number of host cell DNA sensors de...
IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces...
<div><p>IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in t...
The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA, was rece...
AbstractHerpes simplex virus (HSV) undergoes a lytic infection in epithelial cells and a latent infe...
<div><p>Interferon-γ inducible factor 16 (IFI16) is a multifunctional nuclear protein involved in tr...
<div><p>Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA...
SummaryInflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function...
ABSTRACT The human interferon-inducible protein IFI16 is an important antiviral factor that binds nu...
The detection of intracellular microbial DNA is critical to appropriate innate immune responses; how...
ABSTRACT Several host cell nuclear factors are known to restrict herpes simplex virus 1 (HSV-1) repl...
<div><p>The innate immune system pattern recognition receptors (PRR) are the first line of host defe...
IFI16, a member of the IFN-inducible PYHIN-200 gene family, displays multifaceted activity due to it...
Human papillomavirus type 16 (HPV16) and other oncogenic viruses have been reported to deregulate im...
The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0...
Sensing of invading DNA virus genomes appear to be triggered by a number of host cell DNA sensors de...
IFI16, an innate immune DNA sensor, recognizes the nuclear episomal herpes viral genomes and induces...
<div><p>IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in t...
The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA, was rece...
AbstractHerpes simplex virus (HSV) undergoes a lytic infection in epithelial cells and a latent infe...
<div><p>Interferon-γ inducible factor 16 (IFI16) is a multifunctional nuclear protein involved in tr...
<div><p>Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA...
SummaryInflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function...
ABSTRACT The human interferon-inducible protein IFI16 is an important antiviral factor that binds nu...
The detection of intracellular microbial DNA is critical to appropriate innate immune responses; how...
ABSTRACT Several host cell nuclear factors are known to restrict herpes simplex virus 1 (HSV-1) repl...
<div><p>The innate immune system pattern recognition receptors (PRR) are the first line of host defe...
IFI16, a member of the IFN-inducible PYHIN-200 gene family, displays multifaceted activity due to it...
Human papillomavirus type 16 (HPV16) and other oncogenic viruses have been reported to deregulate im...
The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0...
Sensing of invading DNA virus genomes appear to be triggered by a number of host cell DNA sensors de...