Add to ORKGThe regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1+ stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin. Diffuse-type cancer development is dependent on inflammation mediated by Cxcl12+ endothelial cells and Cxcr4+ gastric innate lymphoid cells (ILCs). These cells form the perivascular gastric stem cell niche, and Wnt5a produced from ILCs activates RhoA to inhibit anoikis in the E-cadherin-depleted cells. Targeting Cxcr4, ILCs, or Wnt5a inhibits diffuse-type gastric carcinogenesis, providing...
BACKGROUND: Helicobacter infection is the main risk factor in developing gastric cancer. Mesenchymal...
Gastric cancer (GC) is the 4th most common cancer in the world. Although there is lots of informatio...
SummaryProliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively...
© 2015 Elsevier Inc. The regulation and stem cell origin of normal and neoplastic gastric glands are...
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the o...
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the o...
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mous...
Gastric stem cells have been recently identified and are not yet fully characterized. Each gastric g...
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mous...
The lack of reliable molecular markers for normal differentiated epithelial cells limits understandi...
BACKGROUND & AIMS: Gastric cancer evolves in the setting of a pathologic mucosal milieu characterize...
Background & AimsLittle is known about the mechanisms of gastric carcinogenesis, partly because it h...
The acquisition of genetic/epigenetic mutations in long-lived gastrointestinal stem cells leads to t...
Gastric cancer remains a prominent player in worldwide cancer mortality, due to its poor detection a...
Several genetic and environmental factors increase gastric cancer (GC) risk, with Helicobacter pylor...
BACKGROUND: Helicobacter infection is the main risk factor in developing gastric cancer. Mesenchymal...
Gastric cancer (GC) is the 4th most common cancer in the world. Although there is lots of informatio...
SummaryProliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively...
© 2015 Elsevier Inc. The regulation and stem cell origin of normal and neoplastic gastric glands are...
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the o...
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the o...
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mous...
Gastric stem cells have been recently identified and are not yet fully characterized. Each gastric g...
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mous...
The lack of reliable molecular markers for normal differentiated epithelial cells limits understandi...
BACKGROUND & AIMS: Gastric cancer evolves in the setting of a pathologic mucosal milieu characterize...
Background & AimsLittle is known about the mechanisms of gastric carcinogenesis, partly because it h...
The acquisition of genetic/epigenetic mutations in long-lived gastrointestinal stem cells leads to t...
Gastric cancer remains a prominent player in worldwide cancer mortality, due to its poor detection a...
Several genetic and environmental factors increase gastric cancer (GC) risk, with Helicobacter pylor...
BACKGROUND: Helicobacter infection is the main risk factor in developing gastric cancer. Mesenchymal...
Gastric cancer (GC) is the 4th most common cancer in the world. Although there is lots of informatio...
SummaryProliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively...