Add to ORKGWithin the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1+ tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa. Cholinergic stimulation of the gastric epithelium induced nerve growth factor (NGF) expression, and in turn NGF overexpression within gastric epithelium expanded enteric nerves and promoted carcinogenesis. Ablation of Dclk1+ cells or blockade of NGF/Trk signaling inhibited epithelial proliferation and tumorigenesis in an ACh muscarinic receptor-3 (M3R)-dependent manner, in part through suppression of yes-associated protein (YAP) function. This f...
Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor...
Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, ...
Our understanding of the fascinating connection between nervous system and gastrointestinal (GI) tum...
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem...
The nervous system plays an important role in the regulation of epithelial homeostasis and has also ...
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processe...
International audienceGastric cancer is the third leading cause of cancer-related death worldwide, b...
Cancers often cause excruciating pain and rapid weight loss, severely reducing quality of life in ca...
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processe...
The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and imm...
Objective: This study aimed to address the status, role, and mechanism of sympathetic nerve infiltra...
International audiencelapsing intestinal inflammation that favours the development of colitis associ...
Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have b...
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we ...
Cholinergic signaling, which modulates cell activities via nicotinic and muscarinic acetylcholine re...
Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor...
Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, ...
Our understanding of the fascinating connection between nervous system and gastrointestinal (GI) tum...
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem...
The nervous system plays an important role in the regulation of epithelial homeostasis and has also ...
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processe...
International audienceGastric cancer is the third leading cause of cancer-related death worldwide, b...
Cancers often cause excruciating pain and rapid weight loss, severely reducing quality of life in ca...
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processe...
The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and imm...
Objective: This study aimed to address the status, role, and mechanism of sympathetic nerve infiltra...
International audiencelapsing intestinal inflammation that favours the development of colitis associ...
Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have b...
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we ...
Cholinergic signaling, which modulates cell activities via nicotinic and muscarinic acetylcholine re...
Perineural invasion (PNI) is thought to be one of the factors responsible for the high rate of tumor...
Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, ...
Our understanding of the fascinating connection between nervous system and gastrointestinal (GI) tum...