Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases, however, due to the lack of routine monitoring, the pathology remains severely under-diagnosed and prevalence in the general population is not known. We have developed a set of machine learning methods to quantitate levels of abdominal aortic calcification (AAC) in the UK Biobank imaging cohort and carried out the largest to-date analysis of genetic, biochemical, and epidemiological risk factors associated with the pathology. In a genetic association study, we identified three novel loci associated with AAC (FGF9, NAV9, and APOE), and replicated a previously reported association at the TWIST1/HDAC9 locus. We find that AAC is a highly prevale...
<p><strong>Background.</strong> The patients with abdominal aortic calcification have a high risk of...
Objectives: Vascular calcification is a complicating factor observed in advanced atherosclerosis. T...
Context Abdominal aortic calcification (AAC) is a common finding in patients with atherosclerosis. O...
Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases,...
INTRODUCTION: Abdominal aortic calcification (AAC) is an important marker of subclinical cardiovascu...
AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incom...
Arterial calcification is a well-known risk factor for coronary artery disease (CAD) and myocardial ...
Background—Atherosclerosis is a systemic disease that underlies clinical cardiovascular disease. The...
AbstractArterial calcification is a well-known risk factor for coronary artery disease (CAD) and myo...
Background/Aims: Abdominal aortic calcification (AAC) is associated with incident clinical cardiovas...
Aortic calcification is an important independent predictor of future cardiovascular events. We perfo...
Aortic calcification is an important independent predictor of future cardiovascular events. We perfo...
Context: Abdominal aortic calcification (AAC) is a common finding in patients with atherosclerosis. ...
Objective: To examine the association between aortic arch calcification (AAC) and vascular disease i...
Abdominal aortic aneurysm (AAA) is a balloon like dilation found in the distal aorta. Efforts to lim...
<p><strong>Background.</strong> The patients with abdominal aortic calcification have a high risk of...
Objectives: Vascular calcification is a complicating factor observed in advanced atherosclerosis. T...
Context Abdominal aortic calcification (AAC) is a common finding in patients with atherosclerosis. O...
Calcification of large arteries is a high-risk factor in the development of cardiovascular diseases,...
INTRODUCTION: Abdominal aortic calcification (AAC) is an important marker of subclinical cardiovascu...
AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incom...
Arterial calcification is a well-known risk factor for coronary artery disease (CAD) and myocardial ...
Background—Atherosclerosis is a systemic disease that underlies clinical cardiovascular disease. The...
AbstractArterial calcification is a well-known risk factor for coronary artery disease (CAD) and myo...
Background/Aims: Abdominal aortic calcification (AAC) is associated with incident clinical cardiovas...
Aortic calcification is an important independent predictor of future cardiovascular events. We perfo...
Aortic calcification is an important independent predictor of future cardiovascular events. We perfo...
Context: Abdominal aortic calcification (AAC) is a common finding in patients with atherosclerosis. ...
Objective: To examine the association between aortic arch calcification (AAC) and vascular disease i...
Abdominal aortic aneurysm (AAA) is a balloon like dilation found in the distal aorta. Efforts to lim...
<p><strong>Background.</strong> The patients with abdominal aortic calcification have a high risk of...
Objectives: Vascular calcification is a complicating factor observed in advanced atherosclerosis. T...
Context Abdominal aortic calcification (AAC) is a common finding in patients with atherosclerosis. O...