Cell proliferation and genome dilution in lung adenocarcinomas.
- Clifford W. Sandlin (13919632)
- Song Gu (590521)
- Jun Xu (45543)
- Charuhas Deshpande (605834)
- Michael D. Feldman (9138926)
- Matthew C. Good (5118152)
Publication date
October 2022
DOI Publisher
Public Library of Science (PLoS)Abstract
A., Ki-67 proliferation marker is observed in cells across the range of volumes for LA. Green, Ki67, with merge to CK7, red and DNA, cyan at right. Quantitation of nuclear size data in proliferating cells is shown in Fig 7A, and related to S23 and S24 Figs. B, Estimated ploidy per unit volume within the nucleus, or genome concentration, plotted as a function of cell volume shows that nearly all cells with a volume greater than 2 pL display diluted genomes. n = 4082, related to S1 Data, tab B. (PDF)</p
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