Supplementary Materials - Metabolic labeling unveils alterations in the turnover of plasma proteins during diabetes progression in mice.

Content: Supplementary Methods: Materials. Measurement of body water deuterium enrichment. HDL isolation. Supplementary Results: Supplementary Figures: Supplementary Figure S1: Body water enrichment in control, pre-diabetic (HFD) and diabetic (HFD+STZ) mice. Supplementary Figure S2: overlap between lists of proteins with significantly changed turn-over rates between pairwise comparisons Supplementary Figure S3: STRING interaction network of HDL proteins with altered turnover rates. Supplementary Figures: Supplementary Table S1. Extracted signal intensities of isotope envelope. Time course of deuterium incorporation into quantified peptides. Supplementary Table S2. Turnover rate constants of quantified peptides. Supplementary Table S3. Turnover rates of HDL proteins. Supplementary Table S4. Turnover rates fold changes of proteins due to pre-diabetes and diabetes shown on Figure 4. Supplementary Table S5. Lists of proteins with significantly changed turnover rates between pairwise comparisons shown on Supplementary Figure 2. Supplementary Table S6. Lists of proteins enriched in functionally related gene ontology (GO) categories shown on Figure 6.