Synovial sarcoma of children and adolescents: The prognostic role of axial sites
- FERRARI A
- COLLINI P
- MEAZZA C
- INDOLFI P
- GARAVENTA A
- DE SIO L
- D'ANGELO P
- TAMARO P
- CASANOVA M
- BISOGNO, GIANNI
- ALAGGIO, RITA
- CECCHETTO, GIOVANNI
- ROSOLEN, ANGELO
- CARLI, MODESTO OTTAVIANO
DOIAbstract
BACKGROUND: The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours. METHODS: The present study analysed a series of 115 consecutive SS patients treated in Italian paediatric protocols (period 1979-2005), mainly focusing on the 30 cases arising from 'axial' sites (16 head-neck, 8 trunk, 4 lung-pleura and 2 retroperitoneum). RESULTS: Initial gross resection was achieved in 40% of axial cases and in 80% of limb SS (p<0.0001). Five-year EFS and overall survival (OS) were, respectively, 43.3% and 55.1% for axial SS, and 69.6% (p=0.0068) and 84.0% (p=0.0004) for extremity SS. Local progression/recurrence was the cause of treatment failure in 75% of relapsing patients axial...
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