Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that first occurred in Wuhan in December 2019. The spike glycoproteins and nucleocapsid proteins are the most common targets for the development of vaccines and antiviral drugs. Objective: We herein analyze the rate of evolution along with the sequences of spike and nucleo-capsid proteins in relation to the spatial locations of their epitopes, previously suggested to con-tribute to the immune response caused by SARS-CoV-2 infections. Methods: We compare homologous proteins of seven human coronaviruses: HCoV-229E, HCoV--OC43, SARS-CoV, HCoV-NL63, HCoV-HKU1, MERS-CoV, and SARS-CoV-2. We then focus on the local, structural order-disorder propensity of the...
The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the ...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translat...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that first...
International audienceWe analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2...
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome cor...
BACKGROUND: The striking difference in severity of SARS CoV2 infection among global population is pa...
Epitopes are short amino acid sequences that define the antigen signature to which an antibody or T ...
Several research lines are currently ongoing to address the multitude of facets of the pandemic COVI...
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Sev...
[[abstract]]The spike (S) glycoprotein is thought to play a complex and central role in the biology ...
With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has e...
Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under dev...
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a virus that causes the respiratory ...
The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the ...
The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the ...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translat...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that first...
International audienceWe analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2...
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome cor...
BACKGROUND: The striking difference in severity of SARS CoV2 infection among global population is pa...
Epitopes are short amino acid sequences that define the antigen signature to which an antibody or T ...
Several research lines are currently ongoing to address the multitude of facets of the pandemic COVI...
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Sev...
[[abstract]]The spike (S) glycoprotein is thought to play a complex and central role in the biology ...
With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has e...
Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under dev...
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a virus that causes the respiratory ...
The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the ...
The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the ...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
The efficacy of SARS-CoV-2 nucleic acid-based vaccines may be limited by proteolysis of the translat...