The dissection of the circadian clock into its molecular components represents the most striking and well-studied example of a gene regulatory network underlying a complex behavioural trait. By contrast, the evolutionary analysis of the clock has developed more slowly. Here we review studies that have surveyed intraspecific clock gene variation over large geographical areas and have discovered latitudinal clines in gene frequencies. Such spatial patterns traditionally suggest that natural selection shapes genetic variation, but it is equally possible that population history, or a mixture of demography and selection, could contribute to the clines. We discuss how population genetics, together with functional assays, can illuminate these poss...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Circadian rhythms are daily internal predictive biological cycles. Numerous studies have associated ...
The clock gene period encodes a repetitive series of Threonine-Glycine (Thr-Gly) pairs in D. melanog...
Nearly all studies of natural variation within clock genes involve the period (per) locus, which was...
The clock gene period determines biological rhythmicity in Drosophila melanogaster and encodes a pro...
Circadian rhythms are oscillations in behavior, metabolism and physiology that have a period close t...
Circadian clocks give rise to daily oscillations in behavior and physiological functions that often ...
Circadian clocks give rise to daily oscillations in behavior and physiological functions that often ...
Properties of the circadian and annual timing systems are expected to vary systematically with latit...
The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but w...
Properties of the circadian and annual timing systems are expected to vary systematically with latit...
After a slow start, the comparative analysis of clock genes in insects has developed into a mature a...
BackgroundDrosophila melanogaster often shows correlations between latitude and phenotypic or geneti...
After a slow start, the comparative analysis of clock genes in insects has developed into a mature a...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Circadian rhythms are daily internal predictive biological cycles. Numerous studies have associated ...
The clock gene period encodes a repetitive series of Threonine-Glycine (Thr-Gly) pairs in D. melanog...
Nearly all studies of natural variation within clock genes involve the period (per) locus, which was...
The clock gene period determines biological rhythmicity in Drosophila melanogaster and encodes a pro...
Circadian rhythms are oscillations in behavior, metabolism and physiology that have a period close t...
Circadian clocks give rise to daily oscillations in behavior and physiological functions that often ...
Circadian clocks give rise to daily oscillations in behavior and physiological functions that often ...
Properties of the circadian and annual timing systems are expected to vary systematically with latit...
The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but w...
Properties of the circadian and annual timing systems are expected to vary systematically with latit...
After a slow start, the comparative analysis of clock genes in insects has developed into a mature a...
BackgroundDrosophila melanogaster often shows correlations between latitude and phenotypic or geneti...
After a slow start, the comparative analysis of clock genes in insects has developed into a mature a...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Period 2 (PER2) is a key component of the mammalian circadian clock machinery. In humans, genetic va...
Circadian rhythms are daily internal predictive biological cycles. Numerous studies have associated ...