99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy

Frantellizzi V.
Pontico M.
de Vincentis G.
Civitelli L.
Petronella F.
Pani R.
Calogero A.
Perotto G.
de Sio L.

Publication date

January 2021

Publisher

The Optical Society

Abstract

We report and discuss the synthesis and characterization of a new generation of radiolabeled 99mTc keratin gold nanoparticles (99mTc-Ker-AuNPs) to realize a new generation of biocompatible nanotherapeutics for the treatment of cancerous tissues via light assisted thermal therapy. The presence of 99mTc easily allows revealing the Ker-AuNPs accumulation in tissues, thus enabling a selective photothermal ablation. The 99mTc-Ker-AuNPs is investigated through instant thin-layer chromatography (ITLC), UV-Vis spectroscopy, and a high resolution thermographic optical setup, revealing a successful conjugation between99mTc-Ker and Ker-AuNPs along with excellent photothermal properties

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99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy

Abstract

Extracted data

99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy

Abstract

Extracted data

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