The clinical era of solid organ transplantation started with a renal transplantation (RT) performed between identical twins in Boston in 1954. The patient did not receive any immunosuppression, thus representing the very first case of operational tolerance (Tol). However, more than half a century later, we must admit the inadequacy of our knowledge regarding such a fundamental aspect of transplant immunology, as demonstrated by the fact that Tol has never been achieved in an intention-to-treat protocol. Herein we aim to shortly review the worldwide experience on clinical operational Tol after RT. Thus far, reports on successful cases of Tol after RT have been anecdotal: the largest series included no more than 10 individuals. We will unders...
Purpose of reviewThe attainment of tolerance remains a highly desirable goal in recipients of kidney...
There is still little understanding of the immune events that occur in transplant patients as they d...
Research in Tolerance and Chimerism by Transplant immunologists for over half a century is akin to t...
Item does not contain fulltextWe report here on a European cohort of 27 kidney transplant recipients...
The 20th century represents a breakthrough in the transplantation era, since the first kidney transp...
Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology...
Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology...
Kidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive dru...
Abstract Although transplantation has been a standard med-ical practice for decades, marked morbidit...
Background Kidney recipients maintaining a prolonged allograft survival in the absence of immunosupp...
Background Renal transplant recipients (RTR) frequently develop complications relating to chronic im...
Operational tolerance is defined as stable renal function in transplants without immunosuppression f...
There is still little understanding of the immune events that occur in transplant patients as they d...
Purpose of reviewThe attainment of tolerance remains a highly desirable goal in recipients of kidney...
There is still little understanding of the immune events that occur in transplant patients as they d...
Research in Tolerance and Chimerism by Transplant immunologists for over half a century is akin to t...
Item does not contain fulltextWe report here on a European cohort of 27 kidney transplant recipients...
The 20th century represents a breakthrough in the transplantation era, since the first kidney transp...
Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology...
Since the first solid organ transplant between the Herrick twins in 1954, transplantation immunology...
Kidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive dru...
Abstract Although transplantation has been a standard med-ical practice for decades, marked morbidit...
Background Kidney recipients maintaining a prolonged allograft survival in the absence of immunosupp...
Background Renal transplant recipients (RTR) frequently develop complications relating to chronic im...
Operational tolerance is defined as stable renal function in transplants without immunosuppression f...
There is still little understanding of the immune events that occur in transplant patients as they d...
Purpose of reviewThe attainment of tolerance remains a highly desirable goal in recipients of kidney...
There is still little understanding of the immune events that occur in transplant patients as they d...
Research in Tolerance and Chimerism by Transplant immunologists for over half a century is akin to t...