An intracerebroventricular injection of amyloid-beta peptide (1–42) aggregates modifies daily temporal organization of clock factors expression, protein carbonyls and antioxidant enzymes in the rat hippocampus

Navigatore Fonzo, Lorena Silvina
Alfaro, Mauro
Mazaferro, Paula
Golini, Rebeca Laura Susana
Leporatti, Jorge
Della Vedova, Maria Cecilia
Ramirez, Dario
Delsouc, María Belén
Casais, Marilina
Anzulovich Miranda, Ana Cecilia

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Publication date

September 2021

DOI

10.1016/j.brainres.2021.147449

Publisher

Elsevier BV

Journal

Brain Research

Language

English

Abstract

Alzheimer disease (AD) is the most frequent form of dementia in the elderly. It is characterized by the deterioration of memory and learning. The histopathological hallmarks of AD include the presence of extracellular deposits of amyloid beta peptide, intracellular neurofibrillary tangles, neuron and synapse loss, in the brain, including the hippocampus. Accumulation of Aβ peptide causes an increase in intracellular reactive oxygen species (ROS) and free radicals associated to a deficient antioxidant defense system. Besides oxidative stress and cognitive deficit, AD patients show alterations in their circadian rhythms. The objective of this work was to investigate the effects of an intracerebroventricular injection of amyloid beta peptide A...