Salvia hispanica L. (chia) seed improves skeletal muscle lipotoxicity and insulin sensitivity in rats fed a sucrose-rich diet by modulating intramuscular lipid metabolism
- Ferreira Cordoneda, Maria del Rosario
- Oliva, Maria Eugenia
- Aiassa, Victoria
- D'alessandro, Maria Eugenia Guadalupe
DOIAbstract
This study investigates the possible mechanisms involved in the beneficial effect of chia seed on skeletal muscle lipotoxicity and insulin resistance in rats fed a sucrose-rich diet (SRD). Results showed that chia seed reduced the increased lipid content in the skeletal muscle of SRD-fed rats. This was accompanied by an increase of muscle-type carnitine palmitoyltransferase 1 enzyme activity, peroxisome proliferator-activated receptors (PPARα, PPARγ) and phosphorylated AMP activated protein kinase protein levels. Moreover, the precursor and mature forms of sterol regulatory element-binding protein-1 and lipogenic enzyme activities were decreased. Fatty acid translocase FAT/CD 36 and n-3/n-6 fatty acids ratio of membrane phospholipids were i...
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