In situ vaccination is a promising immunotherapeutic approach, where various local ablative therapies are used to induce an immune response against tumor antigens that are released from the therapy-killed tumor cells. We recently proposed using intratumoral gene electrotransfer for concomitant transfection of a cytotoxic cytokine tumor necrosis factor-% (TNF%) to induce in situ vaccination, and an immunostimulatory cytokine interleukin 12 (IL-12) to boost the primed immune response. Here, our aim was to test the local and systemic effectiveness of the approach in tree syngeneic mouse tumor models and associate it with tumor immune profiles, characterized by tumor mutational burden, immune infiltration and expression of PD-L1 and MHC-I on tu...
[[abstract]]©1996 IIAR - New strategies are becoming available that promise to revolutionize cancer ...
PurposeIL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic ...
Effective eradication of established tumors and generation of a lasting systemic immune response is ...
Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80%...
The development over the past few years has shown that gene therapy has become a true perspective. B...
Tumor formation and growth depends mainly on the inability of the organism to elicit a potent immune...
The safest and most effective cytokine therapies require the favorable accumulation of the cytokine ...
Systemic cancer immunotherapies including checkpoint blockade antibodies targeting the PD-1/PD-L1 ax...
Owing to its tumor tropism and prolonged transgene expression, mesenchymal stem cell (MSC) has been ...
Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low ...
Intratumoral delivery of plasmid IL12 via electroporation (IT-tavo-EP) induces localized expression ...
Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin ...
Two approaches to immunological intervention in tumor–host interactions in mouse models are discusse...
Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host i...
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and t...
[[abstract]]©1996 IIAR - New strategies are becoming available that promise to revolutionize cancer ...
PurposeIL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic ...
Effective eradication of established tumors and generation of a lasting systemic immune response is ...
Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80%...
The development over the past few years has shown that gene therapy has become a true perspective. B...
Tumor formation and growth depends mainly on the inability of the organism to elicit a potent immune...
The safest and most effective cytokine therapies require the favorable accumulation of the cytokine ...
Systemic cancer immunotherapies including checkpoint blockade antibodies targeting the PD-1/PD-L1 ax...
Owing to its tumor tropism and prolonged transgene expression, mesenchymal stem cell (MSC) has been ...
Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low ...
Intratumoral delivery of plasmid IL12 via electroporation (IT-tavo-EP) induces localized expression ...
Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin ...
Two approaches to immunological intervention in tumor–host interactions in mouse models are discusse...
Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host i...
Multimodal treatment approaches, such as radio-immunotherapy, necessitate regimen optimization and t...
[[abstract]]©1996 IIAR - New strategies are becoming available that promise to revolutionize cancer ...
PurposeIL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic ...
Effective eradication of established tumors and generation of a lasting systemic immune response is ...