Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: A pathway analysis of genome-wide association studies
- Julian-Serrano S.
- Yuan F.
- Wheeler W.
- Benyamin B.
- Machiela M. J.
- Arslan A. A.
- Beane-Freeman L. E.
- Bracci P. M.
- Duell E. J.
- Du M.
- Gallinger S.
- Giles G. G.
- Goodman P. J.
- Kooperberg C.
- Marchand L. L.
- Neale R. E.
- Shu X. -O.
- Van Den Eeden S. K.
- Visvanathan K.
- Zheng W.
- Albanes D.
- Andreotti G.
- Ardanaz E.
- Babic A.
- Berndt S. I.
- Brais L. K.
- Brennan P.
- Bueno-De-Mesquita B.
- Buring J. E.
- Chanock S. J.
- Childs E. J.
- Chung C. C.
- Fabianova E.
- Foretova L.
- Fuchs C. S.
- Gaziano J. M.
- Gentiluomo M.
- Giovannucci E. L.
- Goggins M. G.
- Hackert T.
- Hartge P.
- Hassan M. M.
- Holcatova I.
- Holly E. A.
- Hung R. I.
- Janout V.
- Kurtz R. C.
- Lee I. -M.
- Malats N.
- McKean D.
- Milne R. L.
- Newton C. C.
- Oberg A. L.
- Perdomo S.
- Peters U.
- Porta M.
- Rothman N.
- Schulze M. B.
- Sesso H. D.
- Silverman D. T.
- Thompson I. M.
- Wactawski-Wende J.
- Weiderpass E.
- Wenstzensen N.
- White E.
- Wilkens L. R.
- Yu H.
- Zeleniuch-Jacquotte A.
- Zhong J.
- Kraft P.
- Li D.
- Campbell P. T.
- Petersen G. M.
- Wolpin B. M.
- Risch H. A.
- Amundadottir L. T.
- Klein A. P.
- Yu K.
- Stolzenberg-Solomon R. Z.
DOIAbstract
Background: Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are known to cause iron overload and hemochromatosis. Objectives: The objective of this study was to determine whether common genetic variation in the hepcidin-regulating iron metabolism pathway is associated with PDAC. Methods: We conducted a pathway analysis of the hepcidin-regulating genes using single nucleotide polymorphism (SNP) summary statistics generated from 4 genome-wide association studies in 2 large consortium studies using the summary data-based adaptive rank truncated product...
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