Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD
- Cacciamani F.
- Sambati L.
- Houot M.
- Habert M. -O.
- Dubois B.
- Epelbaum S.
- Audrain C.
- Auffret A.
- Bakardjian H.
- Baldacci F.
- Batrancourt B.
- Benakki I.
- Benali H.
- Bertin H.
- Bertrand A.
- Boukadida L.
- Cacciamani F.
- Causse V.
- Cavedo E.
- Cherif Touil S.
- Chiesa P. A.
- Colliot O.
- Dalla Barba G.
- Depaulis M.
- Dos Santos A.
- Dubois B.
- Dubois M.
- Epelbaum S.
- Fontaine B.
- Francisque H.
- Gagliardi G.
- Genin A.
- Genthon R.
- Glasman P.
- Gombert F.
- Habert M. O.
- Hampel H.
- Hewa H.
- Houot M.
- Jungalee N.
- Kas A.
- Kilani M.
- La Corte V.
- Le Roy F.
- Lehericy S.
- Letondor C.
- Levy M.
- Lista S.
- Lowrey M.
- Ly J.
- Makiese O.
- Masetti I.
- Mendes A.
- Metzinger C.
- Michon A.
- Mochel F.
- Nait Arab R.
- Nyasse F.
- Perrin C.
- Poirier F.
- Poisson C.
- Potier M. C.
- Ratovohery S.
- Revillon M.
- Rojkova K.
- Santos-Andrade K.
- Schindler R.
- Servera M. C.
- Seux L.
- Simon V.
- Skovronsky D.
- Thiebaut M.
- Uspenskaya O.
- Vlaincu M.
DOIAbstract
Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages. Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score. Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ...
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