Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study
- Baldacci F.
- Lista S.
- Manca M. L.
- Chiesa P. A.
- Cavedo E.
- Lemercier P.
- Zetterberg H.
- Blennow K.
- Habert M. -O.
- Potier M. C.
- Dubois B.
- Vergallo A.
- Hampel H.
- Bakardjian H.
- Benali H.
- Bertin H.
- Bonheur J.
- Boukadida L.
- Boukerrou N.
- Chiesa P.
- Colliot O.
- Dubois M.
- Epelbaum S.
- Gagliardi G.
- Genthon R.
- Houot M.
- Kas A.
- Lamari F.
- Levy M.
- Metzinger C.
- Mochel F.
- Nyasse F.
- Poisson C.
- Potier M. -C.
- Revillon M.
- Santos A.
- Andrade K. S.
- Sole M.
- Surtee M.
- de Schotten M. T.
- Younsi N.
- Afshar M.
- Aguilar L. F.
- Akman-Anderson L.
- Arenas J.
- Avila J.
- Babiloni C.
- Baldacci F.
- Batrla R.
- Benda N.
- Black K. L.
- Bokde A. L. W.
- Bonuccelli U.
- Broich K.
- Cacciola F.
- Caraci F.
- Caruso G.
- Castrillo J.
- Ceravolo R.
- Corbo M.
- Corvol J. -C.
- Claudio A.
- Cummings J. L.
- Depypere H.
- Duggento A.
- Emanuele E.
- Escott-Price V.
- Federoff H.
- Ferretti M. T.
- Fiandaca M.
- Frank R. A.
- Garaci F.
- Geerts H.
- Giacobini E.
- Giorgi F. S.
- Goetzl E. J.
- Graziani M.
- Haberkamp M.
- Hanisch B.
- Herholz K.
- Hernandez F.
- Imbimbo B. P.
- Kapogiannis D.
- Karran E.
- Kiddle S. J.
- Kim S. H.
- Koronyo Y.
- Koronyo-Hamaoui M.
- Langevin T.
- Lehericy S.
- Llavero F.
- Lorenceau J.
- Lucia A.
- Mango D.
- Mapstone M.
- Neri C.
- Nistico R.
- O'Bryant S. E.
- Palermo G.
- Perry G.
- Ritchie C.
- Rossi S.
- Saidi A.
- Santarnecchi E.
- Schneider L. S.
- Sporns O.
- Toschi N.
- Valenzuela P. L.
- Vellas B.
- Verdooner S. R.
- Villain N.
- Virecoulon Giudici K.
- Watling M.
- Welikovitch L. A.
- Woodcock J.
- Younesi E.
- Zugaza J. L.
DOIAbstract
Background: Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer’s disease (AD). The impact of biological factors on their plasma concentrations in individuals with subjective memory complaints (SMC) has been poorly explored. We longitudinally investigate the effect of sex, age, APOE ε4 allele, comorbidities, brain amyloid-β (Aβ) burden, and cognitive scores on plasma NFL and t-Tau concentrations in cognitively healthy individuals with SMC, a condition associated with AD development. Methods: Three hundred sixteen and 79 individuals, respectively, have baseline and three-time point assessments (at baseline, 1-year, and 3-year follow-up) of the two biomarkers. Plasma biomarker...
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