Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors through regulation of acetyl-CoA metabolism
Epigenetic alterations contribute to tumor development, progression, and therapeutic response. Many ...
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels...
Acetylation is a highly abundant and dynamic post-translational modification (PTM) on histone protei...
SummaryHistone acetylation plays important roles in gene regulation, DNA replication, and the respon...
Histone acetylation plays important roles in gene regulation, DNA replication, and the response to D...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
SummaryHistone acetylation plays important roles in gene regulation, DNA replication, and the respon...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
Both cellular nutrient metabolism and chromatin organization are remodeled in cancer cells, and thes...
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels...
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and t...
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and t...
Alterations in cellular metabolism in tumor cells have been shown to regulate histone acetylation th...
Cancer tissues with lower global levels of histone acetylation display significantly increased rate ...
Epigenetic alterations contribute to tumor development, progression, and therapeutic response. Many ...
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels...
Acetylation is a highly abundant and dynamic post-translational modification (PTM) on histone protei...
SummaryHistone acetylation plays important roles in gene regulation, DNA replication, and the respon...
Histone acetylation plays important roles in gene regulation, DNA replication, and the response to D...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
SummaryHistone acetylation plays important roles in gene regulation, DNA replication, and the respon...
Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrient...
Both cellular nutrient metabolism and chromatin organization are remodeled in cancer cells, and thes...
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels...
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and t...
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and t...
Alterations in cellular metabolism in tumor cells have been shown to regulate histone acetylation th...
Cancer tissues with lower global levels of histone acetylation display significantly increased rate ...
Epigenetic alterations contribute to tumor development, progression, and therapeutic response. Many ...
SummaryThe finding that chromatin modifications are sensitive to changes in cellular cofactor levels...
Acetylation is a highly abundant and dynamic post-translational modification (PTM) on histone protei...
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