Epithelial ovarian carcinoma (EOC) is the most lethal gynecological tumor, that almost inevitably relapses and develops chemo-resistance. A better understanding of molecular events underlying the biological behavior of this tumor, as well as identification of new biomarkers and therapeutic targets are the prerequisite to improve its clinical management. ZNF521 gene amplifications are present in >6% of OCs and its overexpression is associated with poor prognosis, suggesting that it may play an important role in OC. Increased ZNF521 expression resulted in an enhancement of OC HeyA8 and ES-2 cell growth and motility. Analysis of RNA isolated from transduced cells by RNA-Seq and qRT-PCR revealed that several genes involved in growth, prolife...
BACKGROUND: The oncogenesis of ovarian cancer is poorly understood. The aim of this study was to ide...
Background: Human ovarian carcinoma is a silent killer. Most patients with human ovarian carcinoma a...
SummaryBackgroundHuman ovarian carcinoma is a silent killer. Most patients with human ovarian carcin...
Epithelial ovarian carcinoma (EOC) is the most lethal gynecological tumor, that almost inevitably re...
Endogenous ZNF521 mRNA (A, top panel: qRT-PCR) and protein (A, bottom panel: Nuclear protein detecte...
Zhengling Liu, Zonglan Xu, Yonghui Tian, Hua Yan, Yanyan Lou Department of Gynaecology, Linyi Centr...
Analysis of ZNF521 mutations in a set of 1025 patients [https://www.cbioportal.org] (A). Kaplan-Meie...
Abstract Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). R...
Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is th...
Powerful bioinformatics tools have provided a wealth of novel miRNA–transcription factor networks cr...
Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to target this proce...
Cervical cancer (CC) is one of the most common gynecological malignancies worldwide. Zinc Finger Pro...
[[abstract]]Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to targe...
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estr...
Background: Human ovarian carcinoma is a silent killer. Most patients with human ovarian carcinoma a...
BACKGROUND: The oncogenesis of ovarian cancer is poorly understood. The aim of this study was to ide...
Background: Human ovarian carcinoma is a silent killer. Most patients with human ovarian carcinoma a...
SummaryBackgroundHuman ovarian carcinoma is a silent killer. Most patients with human ovarian carcin...
Epithelial ovarian carcinoma (EOC) is the most lethal gynecological tumor, that almost inevitably re...
Endogenous ZNF521 mRNA (A, top panel: qRT-PCR) and protein (A, bottom panel: Nuclear protein detecte...
Zhengling Liu, Zonglan Xu, Yonghui Tian, Hua Yan, Yanyan Lou Department of Gynaecology, Linyi Centr...
Analysis of ZNF521 mutations in a set of 1025 patients [https://www.cbioportal.org] (A). Kaplan-Meie...
Abstract Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). R...
Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is th...
Powerful bioinformatics tools have provided a wealth of novel miRNA–transcription factor networks cr...
Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to target this proce...
Cervical cancer (CC) is one of the most common gynecological malignancies worldwide. Zinc Finger Pro...
[[abstract]]Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to targe...
Preventive therapy can target hormone-responsive breast cancer (BC) by treatment with selective estr...
Background: Human ovarian carcinoma is a silent killer. Most patients with human ovarian carcinoma a...
BACKGROUND: The oncogenesis of ovarian cancer is poorly understood. The aim of this study was to ide...
Background: Human ovarian carcinoma is a silent killer. Most patients with human ovarian carcinoma a...
SummaryBackgroundHuman ovarian carcinoma is a silent killer. Most patients with human ovarian carcin...