Qualidade de vida, depressão e ansiedade em mulheres com doença trofoblástica gestacional

Objective: To assess quality of life, depression and anxiety in women with gestational trophoblastic disease (GTD) before remission (active disease) of the hydatidiform mole (HM) or gestational trophoblastic neoplasia (GTN) and after remission. Methods: This longitudinal study was conducted among 51 women, assessing aspects of quality of life and psychological impacts using validated questionnaires: World Health Organization Quality of Life (WHOQOL-bref), Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory. (STAI-Y). Results: The study highlights that quality of life (QoL) was “regular”, 68.6% were classified as “absence of depression”, 13.7% as “depression” and 17.6% as “dysphoria” in women with active disease. As for anxiety, the score corresponded to “medium-high anxiety” in both trait-anxiety and state -anxiety. After remission of GTD there was a significant improvement in all variables. In QoL, the improvement was evident in the total (p = 0.023), physical (p = 0.003) and satisfaction with health (p = 0.006) domains, although they were classified as “regular”. As for depression, there was also a significant improvement (p <0.001), as well as in the anxiety-trait (p = 0.003) and state anxiety (p <0.001) inventory score. Conclusion: Regarding QoL, depression and anxiety, no significant differences in results were found in relation to women with active disease. The results were similar, regardless of whether women were waiting remission of HM or with a diagnosis of GTN. In the analysis regarding times T1 and T2 (active disease and disease in remission), we concluded that there was a improvement in QOL, absence of depressive symptoms and anxiety after disease remission.Objetivo: Avaliar a qualidade de vida, depressão e ansiedade em mulheres com doença trofoblástica gestacional, antes da remissão (doença ativa) da mola hidatiforme (MH) ou neoplasia trofoblástica gestacional (NTG) e após a remissão. Método: Estudo longitudinal realizado com 51 mulheres, avaliando aspectos da qualidade de vida e impactos psicológicos, por meio dos questionários validados: World Health Organization Quality of Life (WHOQOL-bref), Beck Depression Inventory (BDI) e Inventário de Ansiedade Traço-Estado (IDATE). Resultados: as pacientes quando com doença ativa, tiveram qualidade de vida (QV) “regular”, 68,6% foram classificadas em “ausência de depressão”, 13,7% em “depressão” e 17,6% em “disforia”. Quanto à ansiedade, tanto na ansiedade-traço como ansiedade-estado, o escore correspondeu à “ansiedade média-alta”. Após a remissão da doença, houve melhora significativa em todas as variáveis. Na QV, a melhora evidenciou-se no domínio total (p=0,023), físico (p=0,003) e em relação à satisfação com a saúde (p=0,006), embora mantivessem QV classificada como “regular”. Quanto à depressão, também houve melhora significativa (p<0,001), assim como no escore do inventário de ansiedade –traço (p=0,003) e ansiedade- estado (p