KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes. Activation of these pathways has been described in numerous pathologies.Ministerio de Ciencia e Innovación, Grant/Award Numbers: PID2019‐110061RB‐ I00, PID2021‐122650OB‐I00, PID2021‐ 123481OB‐I00, PID2021‐125986OB‐I00; Instituto de Salud Carlos III, Grant/Award Number: PI17/01700; Comunidad de Madrid, Grant/Award Number: B2017/BMD‐3827‐ NRF24ADCMPeer reviewe