Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IRdeficient astrocytes show disturbed mitochondrial responses to glucose. While exploring the functional impact of disturbed mitochondrial function in astrocytes, we observed that GFAP-IR KO mice show uncoupling of brain blood flow with glucose uptake. Since IR-deficient astrocytes show higher levels of reactive oxidant species (ROS), this leads to stimulation of hypoxia-inducible factor-1¿ and, consequently, of the vascular endothelial growth factor angiogenic pathway. Indeed, GFAP-IR KO mice show disturbed brain vascularity and blood flow that is normalized by treatment with the anti...
Neuronal activity results in increased blood flow in the brain, a response named functional hyperemi...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...
Circulating insulin enters the brain through mechanisms incompletely characterized. We now report th...
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted respo...
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted respo...
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic g...
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic g...
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activi...
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activi...
Astrocytes are specialised glial cells that integrate distinct inputs arising from neurones, other g...
BACKGROUND: The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are ...
Brain activity requires a flux of glucose to active regions to sustain increased metabolic demands. ...
In order to maintain normal brain function, it is critical that cerebral blood flow (CBF) is matche...
Neuronal activity results in increased blood flow in the brain, a response named functional hyperemi...
Neuronal activity results in increased blood flow in the brain, a response named functional hyperemi...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...
Circulating insulin enters the brain through mechanisms incompletely characterized. We now report th...
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted respo...
Mice with insulin receptor (IR)-deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted respo...
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic g...
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic g...
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activi...
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activi...
Astrocytes are specialised glial cells that integrate distinct inputs arising from neurones, other g...
BACKGROUND: The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are ...
Brain activity requires a flux of glucose to active regions to sustain increased metabolic demands. ...
In order to maintain normal brain function, it is critical that cerebral blood flow (CBF) is matche...
Neuronal activity results in increased blood flow in the brain, a response named functional hyperemi...
Neuronal activity results in increased blood flow in the brain, a response named functional hyperemi...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...
In the human brain, there are at least as many astrocytes as neurons. Astrocytes are known to modula...