Toward a Multi-Omics-Based Single-Cell Environmental Chemistry and Toxicology

Increasing resolution has always been a goal for environmental chemistry and toxicology in their quest to expand knowledge on the transport, biogeochemistry, and sinks of natural- and anthropogenic chemicals in the environment, as well as their functions and effects in ecosystem and human health. Linking biology and chemistry is at the core of environmental sciences, (1) and it is now possible to study comprehensive cell signatures by means of single-cell approaches. The trend toward the analysis of increasingly smaller samples, eventually reaching nanosamples and even single-cell approaches, (1−5) has resulted in massive data sets. The measures at cellular level, at higher temporal and spatial scale resolution, require significant methodological development, but allows for new questions with eventual knowledge breakthroughs.Peer reviewe