Cycling in a crowd: coordination of plant cell division, growth, and cell fate

The reiterative organogenesis that drives plant growth relies on the constant production of new cells, which remain encased by interconnected cell walls. For these reasons, plant morphogenesis strictly depends on the rate and orientation of both cell division and cell growth. Important progress has been made in recent years in understanding how cell cycle progression and the orientation of cell divisions are coordinated with cell and organ growth and with the acquisition of specialized cell fates. We review basic concepts and players in plant cell cycle and division, and then focus on their links to growth-related cues, such as metabolic state, cell size, cell geometry, and cell mechanics, and on how cell cycle progression and cell division are linked to specific cell fates. The etinoblastoma pathway has emerged as a major player in the coordination of the cell cycle with both growth and cell identity, while microtubule dynamics are central in the coordination of oriented cell divisions. Future challenges include clarifying feedbacks between growth and cell cycle progression, revealing the molecular basis of cell division orientation in response to mechanical and chemical signals, and probing the links between cell fate changes and chromatin dynamics during the cell cycleUK Biotechnology and Biological Sciences Research Council Institute Strategic Programme Grant (BB/J004588/1); CG is funded by the European Commission (ERC-2018-AdG_833617), the Ministry of Science and Innovation (RTI2018-094793-B-I00) and institutional grants from Fundacón Ramón Areces and Banco de Santander to the Centro de Biologia Molecular Severo Ocho