Add to ORKGAlthough significant progress has been made in the past few decades demonstrating that adenosine modulates a variety of physiological and pathophysiological processes through the interaction with four subtypes of a family of cell-surface G-protein-coupled receptors, clinical evaluation of some adenosine receptor ligands has been discontinued. Major problems include side effects due to the wide distribution of adenosine receptors, low brain penetration (which is important for the targeting of CNS diseases), short half-life of compounds, or a lack of effects, in some cases perhaps due to receptor desensitization or to low receptor density in the targeted tissue. Currently, three A(2A) adenosine receptor agonists have begun phase III studies. ...
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled me...
Introduction: Adenosine exerts its effects by interacting with G-protein coupled receptors (GPCR) na...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mo...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
adenosine regulates a wide range of physiological functions through specific cell membrane receptors...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Adenosine is involved in a range of physiological and pathological effects through membrane-bound re...
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled me...
Introduction: Adenosine exerts its effects by interacting with G-protein coupled receptors (GPCR) na...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mod...
Although significant progress has been made in the past few decades demonstrating that adenosine mo...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
adenosine regulates a wide range of physiological functions through specific cell membrane receptors...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Since the discovery of the biological effects of adenosine, the development of potent and selective ...
Adenosine is involved in a range of physiological and pathological effects through membrane-bound re...
Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-coupled me...
Introduction: Adenosine exerts its effects by interacting with G-protein coupled receptors (GPCR) na...
Ever since the discovery of the hypotensive and bradycardiac effects of adenosine, adenosine recepto...