Modifications of nanocrystalline cellulose with chitosan for controlled release of drug

A new drug carrier with specific ability are studied by many researchers. Many drug carrier are using materials such as nanocrystalline cellulose and chitosan. By combining these materials, a new ability will be formed. Cerbera manghas as cellulose source will be delignified, bleached and hydrolyzed to produce nanocrystalline cellulose (NCC) and then Chitosan with certain mass ratio will be grafted onto NCC surface by mixed it for 12 hours and known as nanocomposite. Nanocomposite solution will be dried and the used for drug loading and release experiment. The result of this study was nanocrystalline cellulose with promising characteristic was found with sulfuric acid 60 wt.% at 30°C and then used as NCC for nanocomposite preparation. Amoxicillin used as drug model adsorped by nanocomposite made from nanocrystalline cellulose modified with chitosan, the ration were 2:1, 1:1, and 1:2. These composite took about 150 minutes to adsorp and less than 10 hours to release the drug. Cellulose from Cerbera manghas characterized by TGA, while NCC and nanocomposite were characterized by using FTIR, SEM and XRD. The drug solution and SBF were characterized by using UV-Vis Spechtrophotometer