The effect of lipidation on the membrane perturbing activity of peptaibol antibiotics was investigated by performing a comparative study on two synthetic analogues of the natural peptide trichogin GA IV. Both analogues were labeled with a hydrophobic fluorescent probe, but one of them lacked the N-terminal n-octanoyl chain, present in the natural peptide. Spectroscopic studies show that the fatty acyl chain produces two opposite effects: it increases the affinity of the monomeric peptide for the membrane phase, but, at the same time, it favors peptide aggregation in water, thus inhibiting membrane binding by reducing the effective monomer concentration. In the membrane phase the two analogues exhibit the same aggregation and orientation beh...
The interaction of the antimicrobial peptide trichogin GA IV with phospholipid bilayers has been stu...
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-t...
We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiot...
The effect of lipidation on the membrane perturbing activity of peptaibol antibiotics was investigat...
The effect of lipidation on the membrane perturbing activity of peptaibol antibiotics was investigat...
AbstractSynthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to invest...
Synthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to investigate th...
Synthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to investigate th...
Water-membrane partition and aggregation behavior are fundamental aspects of the biological activity...
AbstractWater-membrane partition and aggregation behavior are fundamental aspects of the biological ...
Four analogs of the antimicrobial peptide trichogin GA IV were studied. Their sequences are as follo...
Antibiotic peptides, exhibiting activity against different types of microorganisms, are part of the ...
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic peptaibiotic with an N-te...
Trichogin GA IV is a membrane-active lipopeptide, the antibiotic activity of which was proposed to b...
The interaction of the antimicrobial peptide trichogin GA IV with phospholipid bilayers has been stu...
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-t...
We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiot...
The effect of lipidation on the membrane perturbing activity of peptaibol antibiotics was investigat...
The effect of lipidation on the membrane perturbing activity of peptaibol antibiotics was investigat...
AbstractSynthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to invest...
Synthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to investigate th...
Synthetic fluorescent analogs of the natural lipopeptide trichogin GA IV were used to investigate th...
Water-membrane partition and aggregation behavior are fundamental aspects of the biological activity...
AbstractWater-membrane partition and aggregation behavior are fundamental aspects of the biological ...
Four analogs of the antimicrobial peptide trichogin GA IV were studied. Their sequences are as follo...
Antibiotic peptides, exhibiting activity against different types of microorganisms, are part of the ...
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic peptaibiotic with an N-te...
Trichogin GA IV is a membrane-active lipopeptide, the antibiotic activity of which was proposed to b...
The interaction of the antimicrobial peptide trichogin GA IV with phospholipid bilayers has been stu...
Trichogin GA IV is a short-length (10-amino acid long), mostly hydrophobic, peptaibiotic with an N-t...
We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiot...