Long-term antimicrobial effect of polylactide-based composites suitable for biomedical use

This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended with antimicrobial fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored on vermiculite or graphene oxide matrices in an amount of 1% wt. The prepared samples were characterized by conventional methods, further they were exposed to degradation tests in physiological saline conditions and characterized for their antimicrobial properties using common pathogen microorganisms. It has been proven that the prepared polylactide composites change their antimicrobial effects after being in physiological saline of pH 7 and 9 for 0-6 months. The weight of the composites changed by about 10%, and antimicrobial properties were growing over time. The effectiveness of the composites was confirmed for 6 months at minimum. Therefore, they are suitable for the preparation of temporary stents, catheters or implants suitable for fracture fixation.European Commission, EC: LINKA20364; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Consejo Superior de Investigaciones Científicas, CSIC: CZ.02.2.69/0.0/0.0/19_073/0016945, DGS/INDIVIDUAL/2020-001MSMT Operational program Research, development and education - European Union; CSIC [CZ.02.1.01/0.0/0.0/17_049/0008441]; MSMT Operational Programme Research, Development and Education [CZ.02.1.01/0.0/0.0/17_049/0008441]; [LINKA20364]; [CZ.02.2.69/0.0/0.0/19_073/0016945