[EN] One of the main mechanisms regulating translation is the one based on the phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2 alpha) by the general control non-repressive 2 (GCN2) protein kinase. In yeast, this kinase binds to two scaffold proteins (GCN1 and GCN20), facilitating its activation on translating ribosomes. The homology of the three proteins exists in Arabidopsis. In this species, whereas the kinase is activated under several stress situations, the involvement of the scaffold proteins in those processes is controversial, and a new role for GCN1 in translation, independent of the phosphorylation of eIF2 alpha, has been proposed. Arabidopsis presents five genes with homology to GCN20 (ABCF1 to 5)...
One of the most regulated steps of translation initiation is the recruitment of mRNA by the translat...
GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translatio...
Molecular functions of eukaryotic initiation factor 3 (eIF3) in translation are manifold, encompassi...
[EN] One of the main mechanisms blocking translation after stress situations is mediated by phosphor...
There is a fundamental gap in our understanding of the regulation of translation in plants. None of ...
The three protein complexes known as the PCI complexes {19S Proteasome lid, COP9 signalosome (CSN), ...
A mechanism based on reversible phosphorylation of the α-subunit of eukaryotic initiation factor 2 (...
A key component of the conserved GCN (General Control Non-repressive) signalling pathway in plants i...
The yeast regulatory protein kinase, general control non-derepressible-2 (GCN2) plays a key role in ...
Translational regulation has long been recognized as a vital process in the cell responses to the en...
International audiencePhosphorylation of eIF2alpha provides a key mechanism for down-regulating prot...
The synthesis of proteins – translation – is one of the cellular processes that consume a great deal...
In unstressed conditions, the cap‐binding protein, eIF4E, binds the 5′ cap structure (m7G) on mRNA a...
Eukaryotic cells contain an unusually large cytoplasmic pool of P1/P2 phosphoproteins, which form th...
<div><p>One of the most regulated steps of translation initiation is the recruitment of mRNA by the ...
One of the most regulated steps of translation initiation is the recruitment of mRNA by the translat...
GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translatio...
Molecular functions of eukaryotic initiation factor 3 (eIF3) in translation are manifold, encompassi...
[EN] One of the main mechanisms blocking translation after stress situations is mediated by phosphor...
There is a fundamental gap in our understanding of the regulation of translation in plants. None of ...
The three protein complexes known as the PCI complexes {19S Proteasome lid, COP9 signalosome (CSN), ...
A mechanism based on reversible phosphorylation of the α-subunit of eukaryotic initiation factor 2 (...
A key component of the conserved GCN (General Control Non-repressive) signalling pathway in plants i...
The yeast regulatory protein kinase, general control non-derepressible-2 (GCN2) plays a key role in ...
Translational regulation has long been recognized as a vital process in the cell responses to the en...
International audiencePhosphorylation of eIF2alpha provides a key mechanism for down-regulating prot...
The synthesis of proteins – translation – is one of the cellular processes that consume a great deal...
In unstressed conditions, the cap‐binding protein, eIF4E, binds the 5′ cap structure (m7G) on mRNA a...
Eukaryotic cells contain an unusually large cytoplasmic pool of P1/P2 phosphoproteins, which form th...
<div><p>One of the most regulated steps of translation initiation is the recruitment of mRNA by the ...
One of the most regulated steps of translation initiation is the recruitment of mRNA by the translat...
GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translatio...
Molecular functions of eukaryotic initiation factor 3 (eIF3) in translation are manifold, encompassi...